This book of essays on the first generation of protein drugs made by recombinant protein synthesis is a fascinating melange of gossip science history and opinion covering the 20 or so years since human insulin was first introduced. Recombinant protein drugs have accounted for about 10 of the global prescription drug market the market development was rapid especially in the 21st century which could be called the golden age the sale reached 47 billion in1989 285 billion in 2001 347 billion in 2004 about 41 billion in 2005 and more than 100 billion in 2011 which . Factor ix recombinant albumin fusion protein is a recombinant protein that temporarily replaces the missing coagulation factor ix needed for effective hemostasis in patients with hemophilia b factor ix recombinant albumin fusion protein is comprised of genetically fused recombinant coagulation factor ix and recombinant albumin. The following is a list of notable proteins that are produced from recombinant dna using biomolecular engineering in many cases recombinant human proteins have replaced the original animal derived version used in medicine the prefix rh for recombinant human appears less and less in the literature. Most of the hosts used to produce the 151 recombinant pharmaceuticals so far approved for human use by the food and drug administration fda and or by the european medicines agency emea are microbial cells either bacteria or yeast this fact indicates that despite the diverse bottlenecks and obstacles that microbial systems pose to the efficient production of functional mammalian proteins
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